10 Inspiring Photos of Lonely Planet’s Best U.S. Cities

Philadelphia, Pennsylvania

At number one, Philly is also on our list of 12 Destinations That Should Be on Your Radar in 2016, thanks to its recent recognition as the first and only UNESCO World Heritage City in the U.S. In July, the city will host the Democratic National Convention. Movie fans take note: 2016 is also the 40th anniversary of Rocky.

Natchez, Mississippi

Natchez turns 300 years old this year, and will celebrate with hundreds of festivals and events along the Mississippi river. Don't miss the annual Great Mississippi River Balloon Race in October.

Yellowstone National Park

As the world's first national park, there's no better time to celebrate the National Park Service's centennial year than with a visit to Yellowstone. Old Faithful geyser has a new boardwalk and the park and nearby towns have been preparing for the expected millions of visitors this year.

RELATED: 5 Ways to See Yellowstone in a Weekend

Birmingham, Alabama

This previously industrial city is reinventing itself with an emerging craft beer scene, a variety of museums, nightlife, booming Civil Rights District, and up-and-coming culinary spots (BBQ anyone?).

Alaska

Oftentimes overlooked because of its far-north location, Alaska boasts incredible national parks, and should be on the radar for anyone looking to celebrate the National Park centennial with plenty of elbowroom. The state is also home to Denali, America's tallest peak and a national park.

RELATED: 10 Cruises That Should Be on Your Bucket List in 2016

Somerville, Massachusetts

Forget Cambridge, Somerville is Boston's latest hip neighboring city with obscure museums—like the Museum of Bad Art—nightlife, a new music scene, craft breweries, a neighborhood concept called Assembly Row, and new restaurants.

RELATED: What Not to Do in Boston

Northwest Arkansas

Discover an American hidden gem with beautiful blue lakes and rivers, lush peaks, and unique towns. Don't miss Fayetteville for an artsy vibe and Eureka Springs for amazing hiking.

San Antonio, Texas

If you're looking for a unique Texas experience, San Antonio is where it's at for 2016. From the recently expanded River Walk to its Brewery District, you'll find incredible food, nightlife, outdoor events, and Mexican culture in this city.

Southern New Mexico

You'll find some strange, yet weirdly fascinating sites in this region. From the jaw-dropping White Sands National Monument, to the Organ Mountains Desert Peaks National Monument, where World War II bombers and NASA astronauts trained, you'll be fully immersed in the wild, wild West.

RELATED: When to Visit New Mexico

Milwaukee, Wisconsin

While overshadowed by Chicago, Milwaukee is a great destination in itself, particularly when it comes to beer. Find household name and craft breweries—as well as museums and attractions like the Milwaukee Art Museum.

More from SmarterTravel:

• The 14 Places in America You Have to Visit in 2016
• The Best National Parks for Each Season
• America's Best Small Cities on the Rise

Ashley Rossi is always ready for her next trip. Follow her on Twitter and Instagram for more advice on travel hacks and destination ideas.